The NRG was founded in 2004 by Daniel Marcus, while working with Randy Buckner at the Howard Hughes Medical Institute at Washington University in St Louis, and soon after moved to the Mallinckrodt Institute of Radiology at the Washington University School of Medicine. Our primary mission is to support biomedical imaging research, with a focus on neuroimaging. Our projects include software engineering, open access data sharing, and automated diagnostics. A foundation project in the lab is XNAT, an open source imaging informatics platform. (Learn more at www.xnat.org.) XNAT and other NRG software are being used to support a number of projects at Washington University, including studies of Alzheimer’s Disease, Neuro-oncology, and the human connectome, and at many other institutions across the country.
The NRG is a contributing member of the Biomedical Informatics Research Network (BIRN), an NIH-supported organization that is building distributed technologies for addressing informatics challenges, and the National Alliance for Medical Imaging Computing (NA-MIC). Dan and the lab are also part of the informatics team of the Human Connectome Project, a five year NIH project that will map the functional and structural connections in healthy human brains. (Learn more at www.humanconnectome.org)
The NRG is supported by a number research grants.
U01 AG032438-019008 (Marcus) – NIA. 07/16/14 – 12/31/19
Dominantly Inherited Alzheimer Network (DIAN) Informatics Core.
This study uses neuroimaging, genetics, neuropsychology, and other biomarkers to obtain a better understanding of early onset inherited Alzheimer’s disease.
P30 NS098577 (Marcus) – NINDS. 07/14/16 – 06/30/20
NINDS Center Core for Brain Imaging.
The goal of this Center is to enhance the quality, the efficiency, and the diversity of neuroimaging research at our institution.
1 R01 EB009352-01A1 (Marcus) – NIBIB. 04/01/09 – 08/31/17
The XNAT Imaging Informatics Platform.
The overarching aim of this proposal is to develop a comprehensive open source imaging informatics platform built to the highest engineering standards and using the most advanced software technologies available.
R24 MH108315 (Marcus, Van Essen) – NIH. 05/02/16 – 03/31/20
Connectome Coordination Facility.
The goal of this project is to operate a data center for the aggregation, processing, and distribution of multi-modal connectomics and related clinical data obtained by NIH-funded studies of human disease and development.
1 U24 CA204854-01 (Marcus, Wahl) – NIH. 05/16/16 – 04/30/21
Integrative Imaging Informatics for Cancer Research.
The I3CR is developing tools and services to support the development, validation, and clinical use of quantitative imaging biomarkers in cancer treatment and response assessment.
U54 MH091657 (Van Essen) – NIBIB. 09/01/10 – 08/30/15
The Human Connectome Project.
The Human Connectome Project (HCP) will comprehensively map human brain circuitry in 1,200 healthy adults using cutting-edge methods of noninvasive neuroimaging.
U54 EB005149-04 (Kikinis) – NIBIB. 09/17/04 – 07/31/15
National Alliance-Medical Imaging Computing: Washington Univ. Site.
The goal of NA-MIC is to develop computational tools for analysis and visualization of medical image data.
1 R01 NS066905-01 (Marcus) – NINDS. 09/30/09 – 06/30/15
BIRN Resources Facilitate the Personalization of Malignant Brain Tumor Research.
This project is developing the Comprehensive NeuroOncology Data Repository (CONDR), an imaging, genetics, and clinical database to investigate diagnostics and treatment of malignant brain cancer.
P30 HD062171 (Inder) – NIBIB. 07/01/10 – 06/30/15
Washington Univ. Intellectual and Developmental Disabilities Research Center.
The goal of the WUIDDRC is to develop and operate services to support the University’s pediatric research community in investigations of brain development.
U24 RR025736-01 (Kesselman) – NCRR. 12/15/08 – 11/30/13
Bio-Informatics Research Network Coordinating Center (BIRN-CC): WUSTL Site.
The BIRN-CC is developing a backbone software infrastructure to support biomedical research.
U24 RR025736-01 (Rosen) – NCRR. 12/15/08 – 11/30/13
The Morphometry BIRN developed imaging methods and software to support multi-site imaging research.
U24 RR026057 (Rosen) – NCRR. 09/30/09 – 07/31/13
Collaborative Tools Support Network for BIRN.
The BIRN- Support Network provides support services such as consulting, documentation, and training to users of the BIRN infrastructure.
5 R01 MH074916 (Sheline) – NIMH. 4/01/07 – 3/31/11
Vascular Depression: Longitudinal Followup.
Examine the effect of baseline neuroimaging findings and cognitive function in predicting course of illness over a five year follow-up.
P01 AG026276 (Morris) – NIA. 7/01/05 – 6/30/10
Project 1: Antecedent Biomarkers for AD: The Adult Children Study
This program project will examine potential antecedent biomarkers (CSF, blood, MRI, PIB PET, attention profile) in a cohort of middle-aged adults with and without a demented parent.