Carlos Cruchaga, Ph.D., is an Assistant Professor in the Department of Psychiatry at Washington University School of Medicine. Dr. Cruchaga’s research focuses on rare variants in Alzheimer’s disease. In his early research, he collaborated with Dr. Alison Goate, Professor of Genetics & Neurology, and others to study a gene variation that appeared to predict the rate at which Alzheimer’s disease will progress. Their research points to a way to determine how rapidly Alzheimer’s patients may develop full-blown dementia after their diagnosis. By studying high and low levels of tau or amyloid-beta in the cerebrospinal fluid of subjects at risk for Alzheimer’s disease, researchers found that a gene variation can increase the chances of developing Alzheimer’s disease when it occurs in tandem with another gene variant known to elevate risk.
Title: Next-generation sequencing technology to identify novel genes implicated on Alzheimer’s Disease