The Neuroimaging Informatics and Analysis Center is pleased to welcome Donald McLaren, Ph.D. to the 2011 NIL-NIAC Seminar Series.
McLaren’s research at the in the Gerontology Research Unit of the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital and Harvard Medical School focuses on differentiating “normal” from amyloid-dependent “pathological” aging and the development of imaging biomarkers for Alzheimer’s disease (AD) clinical trials using neuropsychological testing in conjunction with functional, structural, and molecular neuroimaging. Specifically, he is developing a generalized form of psychophysiological interactions (gPPI, http://brainmap.wisc.edu/PPI) to be used as a neuroimaging tool and believes that it will have higher sensitivity and specificity for the diagnosis of neurodegenerative disorders, in particular preclinical AD. Additionally, PPI analyses have been used to understand brain networks involved in cognitive (e.g. memory and emotion) and motor (e.g. swallowing) functions.
Topic: An Introduction to a Generalized Form of Psychophysiological Interactions and its Application in Aging and Alzheimer’s Disease