Kelly Botteron, M.D., is a Professor of Psychiatry (Child) and Radiology at Washington University School of Medicine. Dr. Botteron’s clinical research focuses on child and adolescent psychiatry, early onset depression, autism, pervasive developmental disorder, obsessive compulsive disorder, Tourette’s disorder, bipolar affective disorder, schizophrenia, and neuropsychiatry. Her research investigates structural brain differences in children and adolescents with affective disorders, attention deficit disorder and autism. Her lab is examining structural MRI differences in discordant twin populations. They are involved in a longitudinal study to characterize very early brain development with MRI in infants at risk for developing autism and infants with Fragile X. In order to better understand structural abnormalities which they and others are demonstrating in children with psychiatric disorders, they are seeking to better characterize the progress of normal structural development and associated cognitive & behavioral development, by MRI, in healthy control populations. Secondary to ongoing neurodevelopmental changes, image analysis methodologies need specific validation and potential modifications for use in child populations. The Botteron Lab is collaborating with Dr. Michael Miller and Dr. Tilak Ratnanather’s lab (Johns Hopkins University) on an application of newer image analysis techniques, including automated 3-D, high resolution, warping atlases for child and adolescent populations.
Title: Normal Variants & Unexpected Developmental Trajectories: Updates & Implications from the NIH MRI Study of Normal Brain Development.