Dr. Manus Donahue is an Assistant Professor of Radiology and Radiological Sciences with a secondary appointment in the Department of Neurology. Dr. Donahue is a member of the Vanderbilt Memory & Alzheimer’s Center and Vanderbilt University Institute of Imaging Science where his work focuses on developing new MRI methodologies and applying these methodologies to understand human brain function, both in health and disease. His research is focused on developing new approaches for studying structural, functional and chemical adjustments related to brain function, as well as developing quantitative models for interrogating relations between neuronal activity and corresponding hemodynamic and neurochemical adjustments. Dr. Donahue’s work is application-oriented, in which novel methodologies are clinically applied to better understand disease origin and progression, most prominently in stroke and memory-related disorders, such as mild cognitive impairment and Alzheimer’s disease. Since 2012, Dr. Donahue has collaborated with Dr. Jefferson and her laboratory on the Memory & Aging Project and the Alzheimer’s Disease Neuroimaging Initiative dataset to understand how vascular integrity affects the pathogenesis and clinical manifestation of Alzheimer’s disease.
Title: Magnetic resonance imaging of hemodynamic compensation mechanisms in the clinic